TRACK-HD
TRACK-HD is a prospective, multi-national, observational biomarker study in individuals with premanifest and early Huntington's disease (HD) who were recruited from sites in Leiden (Netherlands), London (UK), Paris (France), and Vancouver (Canada). The study involved three groups: participants who are carriers of the mutant HTT gene but did not yet have HD symptoms (premanifest); individuals with early HD; and healthy controls matched by age and sex. All participants underwent clinical, neuropsychiatric, cognitive, motor, oculomotor and MRI assessments at baseline, 12, 24 and 36 months.
Study design
Cohort - clinical
Number of participants at first data collection
123 (control participants)
120 (premanifest gene carrier participants)
123 (early Huntington's Disease participants)
Age at first data collection
Varied (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2008
Primary Institutions
University College London (UCL)
Links
portal.dementiasplatform.uk/CohortDirectory/Item
ucl.ac.uk/ion/sites/ion/files/trackhd-study-protocol-visit_4_version_4.0.pdf
Profile paper DOI
Not available
Funders
CHDI Foundation
Ongoing?
No
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Diffusion Tensor Imaging (DTI)
- Magnetic Resonance Spectroscopy (MRS)
- Positron Emission Tomography (PET)
- None
Engagement
Keywords
