The TREND study aims to investigate molecular characterization and deep phenotyping for chronic non-communicable diseases (NCDs), focusing on providing mechanistic insights with diagnostic, prognostic, and therapeutic implications. The study aims to recruit 20,000 residents 18 years and older of Ma'anshan in the south of Anhui province, China. The first phase took place from August to October 2023 and recruited over 3,000 participants by sampling households surrounding local health centres. Participants will be followed up annually by face-to-face or phone interviews, and additional interviews after the occurrence of any relevant event. Data, samples, and measurements collected during the recruitment phase are systematically recollected at 5, 10, 15, 20, 25, and 30 years after the baseline assessment. Passive follow-up involves collecting self-reports when participants visit the health centre to report events and the Ma'anshan health surveillance system, including data from disease and death registries.

Recruitment is ongoing